Can We Predict Failure of Mitral Valve Repair?

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Can We Predict Failure of Mitral Valve Repair? / Gasser, Simone; von Stumm, Maria; Sinning, Christoph; Schaefer, Ulrich; Reichenspurner, Hermann; Girdauskas, Evaldas.

in: J CLIN MED, Jahrgang 8, Nr. 4, 17.04.2019.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsätzeForschungBegutachtung

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@article{6f98c054297340639e18fc1e85617aa0,
title = "Can We Predict Failure of Mitral Valve Repair?",
abstract = "OBJECTIVE: To identify echocardiographic and surgical risk factors for failure after mitral valve repair.METHODS: We identified a total of 77 consecutive patients from our institutional mitral valve surgery database who required redo mitral valve surgery due to recurrence of mitral regurgitation after primary mitral valve repair. A control group of 138 patients who had a stable echocardiographic long-term result was included based on propensity score matching. Systematic analysis of echocardiographic parameters was performed before primary surgery; after mitral valve repair and prior to redo surgery. Risk factor analysis was performed using multivariate Cox regression model.RESULTS: Redo surgery was associated with the presence of pulmonary hypertension ≥ 50 mmHg (p = 0.02), a mean transmitral gradient > 5 mmHg (p = 0.001), left ventricular ejection fraction ≤ 45% (p = 0.05) before surgery and mitral regurgitation ≥moderate at time of discharge (p = 0.002) in the whole cohort. Patients with functional mitral valve regurgitation had a higher tendency to undergo redo surgery if preoperative left ventricular end-diastolic diameter exceeded 65 mm (p = 0.043) and if postoperative tenting height exceeded 6 mm (p = 0.018). Low ejection fraction was not significantly associated with the need for redo mitral valve surgery in the functional subgroup.CONCLUSIONS: Recurrent mitral regurgitation is still a valuable problem and is associated with relevant perioperative mortality. Patients with severe mitral regurgitation should undergo early mitral valve repair surgery as long as systolic pulmonary artery pressure is low, left ventricular ejection fraction is preserved, and LVEED is deceeds 65 mm.",
author = "Simone Gasser and {von Stumm}, Maria and Christoph Sinning and Ulrich Schaefer and Hermann Reichenspurner and Evaldas Girdauskas",
year = "2019",
month = apr,
day = "17",
doi = "10.3390/jcm8040526",
language = "English",
volume = "8",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Can We Predict Failure of Mitral Valve Repair?

AU - Gasser, Simone

AU - von Stumm, Maria

AU - Sinning, Christoph

AU - Schaefer, Ulrich

AU - Reichenspurner, Hermann

AU - Girdauskas, Evaldas

PY - 2019/4/17

Y1 - 2019/4/17

N2 - OBJECTIVE: To identify echocardiographic and surgical risk factors for failure after mitral valve repair.METHODS: We identified a total of 77 consecutive patients from our institutional mitral valve surgery database who required redo mitral valve surgery due to recurrence of mitral regurgitation after primary mitral valve repair. A control group of 138 patients who had a stable echocardiographic long-term result was included based on propensity score matching. Systematic analysis of echocardiographic parameters was performed before primary surgery; after mitral valve repair and prior to redo surgery. Risk factor analysis was performed using multivariate Cox regression model.RESULTS: Redo surgery was associated with the presence of pulmonary hypertension ≥ 50 mmHg (p = 0.02), a mean transmitral gradient > 5 mmHg (p = 0.001), left ventricular ejection fraction ≤ 45% (p = 0.05) before surgery and mitral regurgitation ≥moderate at time of discharge (p = 0.002) in the whole cohort. Patients with functional mitral valve regurgitation had a higher tendency to undergo redo surgery if preoperative left ventricular end-diastolic diameter exceeded 65 mm (p = 0.043) and if postoperative tenting height exceeded 6 mm (p = 0.018). Low ejection fraction was not significantly associated with the need for redo mitral valve surgery in the functional subgroup.CONCLUSIONS: Recurrent mitral regurgitation is still a valuable problem and is associated with relevant perioperative mortality. Patients with severe mitral regurgitation should undergo early mitral valve repair surgery as long as systolic pulmonary artery pressure is low, left ventricular ejection fraction is preserved, and LVEED is deceeds 65 mm.

AB - OBJECTIVE: To identify echocardiographic and surgical risk factors for failure after mitral valve repair.METHODS: We identified a total of 77 consecutive patients from our institutional mitral valve surgery database who required redo mitral valve surgery due to recurrence of mitral regurgitation after primary mitral valve repair. A control group of 138 patients who had a stable echocardiographic long-term result was included based on propensity score matching. Systematic analysis of echocardiographic parameters was performed before primary surgery; after mitral valve repair and prior to redo surgery. Risk factor analysis was performed using multivariate Cox regression model.RESULTS: Redo surgery was associated with the presence of pulmonary hypertension ≥ 50 mmHg (p = 0.02), a mean transmitral gradient > 5 mmHg (p = 0.001), left ventricular ejection fraction ≤ 45% (p = 0.05) before surgery and mitral regurgitation ≥moderate at time of discharge (p = 0.002) in the whole cohort. Patients with functional mitral valve regurgitation had a higher tendency to undergo redo surgery if preoperative left ventricular end-diastolic diameter exceeded 65 mm (p = 0.043) and if postoperative tenting height exceeded 6 mm (p = 0.018). Low ejection fraction was not significantly associated with the need for redo mitral valve surgery in the functional subgroup.CONCLUSIONS: Recurrent mitral regurgitation is still a valuable problem and is associated with relevant perioperative mortality. Patients with severe mitral regurgitation should undergo early mitral valve repair surgery as long as systolic pulmonary artery pressure is low, left ventricular ejection fraction is preserved, and LVEED is deceeds 65 mm.

U2 - 10.3390/jcm8040526

DO - 10.3390/jcm8040526

M3 - SCORING: Journal articles

C2 - 30999593

VL - 8

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 4

ER -